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Of 702 patients, 11.
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Gastrointestinal Gastrointestinal disturbances are the most common reactions. Gastrointestinal complaints reported that patients treated for 5 to 8 years with diet plus a fixed dose of tolbutamide 1.
A no Prescription Glucotrol Generic increase in total mortality was not observed, but the use of tolbutamide was discontinued based on the increase in cardiovascular mortality, thus limiting the opportunity for the study to show an increase in overall mortality. Despite controversy regarding the interpretation of these results, the findings of the UGDP study provide an adequate basis for this warning. If hypoglycemia should occur in such patients, it may be prolonged and appropriate management should be instituted. Renal or hepatic insufficiency may cause elevated blood levels of GLUCOTROL and the latter may also diminish gluconeogenic capacity, both of which increase the risk of serious hypoglycemic reactions.
Loss Of Control Of Blood Glucose When a patient stabilized on any diabetic regimen is exposed to stress such as fever, trauma, infection, or surgery, a loss of control may occur. Hemolytic Anemia Treatment of patients with glucose 6-phosphate dehydrogenase G6PD deficiency with sulfonylurea agents can lead to hemolytic anemia.
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In post-marketing reports, no Prescription Glucotrol Generic anemia has also been reported been reported more frequently with the use of agents with prolonged half-lives, No Prescription Glucotrol Generic. Pediatric Use Safety and effectiveness in children have not been established. Geriatric Use A determination has not been made whether no Prescription Glucotrol Generic clinical studies of GLUCOTROL included sufficient numbers of subjects aged 65 and over to define a difference in response from younger subjects.
Other reported clinical experience has not identified differences in responses between the elderly and younger patients. Close monitoring should continue until the physician is assured that the patient is out of danger. Severe hypoglycemic reactions with coma, seizure, or no Prescription Glucotrol Generic neurological impairment occur infrequently, but constitute medical emergencies requiring immediate hospitalization. Patients should be closely monitored for a minimum of 24 to 48 hours since hypoglycemia may recur after apparent clinical recovery. Type 1 diabetes mellitus, no Prescription Glucotrol Generic ketoacidosis, with or without coma.
This condition should be treated with insulin. In humans, GLUCOTROL appears to lower the blood glucose acutely by stimulating the release of insulin from the pancreas, an effect dependent upon functioning beta cells in the pancreatic islets. The insulinotropic response to a meal occurs within 30 minutes after an oral dose of GLUCOTROL in diabetic patients, but elevated insulin levels do not persist beyond the time of the meal challenge.
Blood sugar control persists in no Prescription Glucotrol Generic patients for up to 24 hours after a single dose of even though plasma levels have declined to a small fraction of peak levels by that time see Pharmacokinetics below. Peak plasma concentrations occur 1—3 hours no Prescription Glucotrol Generic a single oral dose.
The half-life of elimination ranges from 2—4 hours in normal subjects, whether given intravenously or orally. Total absorption and disposition of an oral dose was unaffected by food in normal volunteers, but absorption was delayed by about 40 minutes. The primary metabolites are inactive hydroxylation products and polar conjugates and are excreted mainly in the urine. The risks of hypoglycemia, its symptoms and treatment, and conditions that predispose to its development should be explained to patients and responsible family members.
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Primary and secondary failure should also be explained, No Prescription Glucotrol Generic. Physician Counseling Information For Patients In treatment for type 2 diabetes, diet should be emphasized as the no Prescription Glucotrol Generic form of treatment. Caloric restriction and weight loss are essential in the obese diabetic patient. Proper dietary management alone may be effective in controlling the blood glucose and symptoms of hyperglycemia. The importance of regular physical activity should also be stressed, and cardiovascular risk factors should be identified and corrective measures taken where possible. Use of GLUCOTROL or other antidiabetic medications must be viewed by both the physician and patient as a treatment in addition to diet and not as a substitution or as a convenient mechanism for avoiding dietary restraint.
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